What role does audience uptake play in determining whether a speaker refuses or consents to sex? Proponents of constitution theories of uptake argue that which speech act someone performs is largely determined by their addressee’s uptake. However, this appears to entail a troubling result: a speaker might be made to perform a speech act of sexual consent against her will. In response, we develop a social constitution theory of uptake. We argue that addressee uptake can constitute a speaker’s utterance of (...) ‘no’ as a speech act of consent under some conditions, but that this does not prevent us from judging that an addressee committed rape. Second, we claim that addressee uptake is not the only form of uptake that matters—the uptake of other members of the discursive community matters too, and can override the addressee’s uptake, constituting the speaker’s utterance as the speech act it was intended to be. (shrink)

This article examines the formation of consciousness among women at the beginning stages of the women's movement. The author analyzes the complexity of pathways to feminism across the political spectrum, comparing women who were active on the Left in Students for a Democratic Society with women active in the leading conservative organization of the 1960s, Young Americans for Freedom. She finds an unexpected division among women in both groups between those who identify discrimination by their male peers and those who (...) do not. The author argues there are three stages in the formation of feminist consciousness: identification of inequality or mistreatment, discovering a language or framing by which to interpret these experiences, and the social construction of a collective identity. Factors for each of these three stages that help or hinder the formation of feminist consciousness are discussed. (shrink)

In this review, we discuss the application of mouse models to the identification and pre‐clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large‐scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross‐species comparative ‘omics‐based approaches to this problem. We highlight recent progress in modelling late‐stage disease using mice, (...) and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection. (shrink)

Children’s fine motor skills link to cognitive development, however, research on their involvement in language processing, also with adults, is scarce. Lexical items are processed differently depending on the degree of sensorimotor information inherent in the words’ meanings, such as whether these imply a body-object interaction or a body-part association. Accordingly, three studies examined whether lexical processing was affected by FMS, BOIness, and body-part associations in children and adults. Analyses showed a differential link between FMS and lexical processing as a (...) function of age. Whereas response latencies indicated that children’s FMS were associated with “hand” words, adults’ FMS linked to the broader concept of BOI. Findings have implications for shared activation theories positing that FMS support lexical processing. (shrink)

Members of the serine/arginine (SR)‐rich protein family of splicing factors play versatile roles in RNA processing steps and are often essential for normal development. Dynamic changes in RNA processing and turnover allow fast cellular adaptions to a changing microenvironment and thereby closely cooperate with transcription factor networks that establish cell identity within tissues. SR proteins play fundamental roles in the processing of pre‐mRNAs by regulating constitutive and alternative splicing. More recently, SR proteins have also been implicated in other aspects of (...) RNA metabolism such as mRNA stability, transport and translation. The‐ emerging noncanonical functions highlight the multifaceted functions of these SR proteins and identify them as important coordinators of gene expression programmes. Accordingly, most SR proteins are essential for normal cell function and their misregulation contributes to human diseases such as cancer. (shrink)

ExcerptI have apologized privately to Prof. Perry—and do so again publicly—for my incorrect notation about her speech and my lack of precise citation. I was unaware of the published article, but had heard the speech at a regional AAS conference. I made assumptions about its nature (not its content) that I should not have done. I do not wish to elaborate here on our different ways of framing historical arguments and questions. Over many years, I have been an admiring reader (...) of Prof. Perry's impressive corpus of work, even as I have disagreed with elements of it (as is normal…. (shrink)

A recent spate of exposés about Mao Zedong's China, in English and Chinese, announces a finality to the tendency toward the temporal-spatial conflation of twentieth-century Chinese and global history. This sense was confirmed when the New York Times reported in late January 2006 that George W. Bush's recent bedtime reading had been Jung Chang and Jon Halliday's Mao: The Unknown Story,1 or when, later in 2006, according to a column in the British paper The Guardian, “the Council of Europe's parliamentary (...) assembly voted to condemn the ‘crimes of totalitarian communist regimes’, linking them with Nazism.”2 The temporal-spatial conflation hence is,…. (shrink)

Elymnion, according to Stephanos, was S000983880002084X_inline4 The name occurs in Aristophanes {Peace, 1126) in a context which points to the neighbourhood of Oreos. There is no evidence to connect it immediately with Chalkis. Mela mentions an Echinia near Akanthos: ' inter Strymona et Athon Turris Calarnaea et portus Capru, urbs Acanthos et Echinia.' Confusion of A and X is easy. Thus, even if the first sentence has no ol, the passage gives no safe evidence that these settlers came to Kleonai (...) from Chalkis, or from Euboea. Such a derivation would be hard to reconcile with Thucydides' account of the towns on Akte. If oί is right, cadit quaestio. (shrink)

Manuel des Études grecques et latines. ParL. Laurand. Fascicule VII.: Métrique, Sciences complémentaires (Critique des textes, Paléographie, Épigraphie, Numismatique, Histoire de la Philologie, Bibliographic, Le Travail philologique): 4e édition, revue et corrigée. Appendices II.-IV.: L'Art oratoire des anciens, L'Enseignement du grec et du latin, Lectures de litterature grecque et latine. Appendice V.: Petit atlas pratique d'histoire grecque et romaine. Paris: Auguste Picard, 1929. - Volume 45 Issue 2.

Ductin is the highest conserved membrane protein yet found in eukaryotes. It is multifunctional, being the subunit c or proteolipid component of the vacuolar H+‐ATPase and at the same time the protein component of a form of gap junction in metazoan animals. Analysis of its structure shows it to be a tandem repeat of two 8‐kDa domains derived from the subunit c of the F0 proton pore from the F1F0 ATPase. Each domain contains two transmembrane α‐helices, which together may form (...) a four‐helix bundle. In both the V‐ATPase and gap junction channel, ductin is probably arranged as a hexamer of subunits forming a central channel of gap junction‐like proportions. The two functions appear to be seggregated by ductin having two orientations in the bilayer. Ductin is also the major component of the mediatophore, a protein complex which may aid in the release of neurotransmitters across the pre‐synaptic membrane. It is also a target for a class of poorly understood viral polypeptides. These polypeptides are small and highly hydrophobic and some have oncogenic activity. Ductin thus appears to be at the crossroads of a number of biological processes. (shrink)

In qualitative research into emotions, researchers and participants share emotion-laden interactions. Few demonstrate how the analytic value of emotions may be harnessed. In this article we provide an account of our emotional experiences conducting research with two groups: adults living with cystic fibrosis and spouse caregivers of cancer patients. We describe our emotion work during research interviews, and discuss its methodological and theoretical implications. Reflections depict competing emotion norms in qualitative research. Experiences of vulnerability and involuntary “emotional callusing” illustrate the (...) insight into participants’ experiences afforded to us through emotion work. This prompted us to extend Hochschild’s theory to incorporate unconscious activity mediated through habitus, allowing us to demonstrate how the “emotional” nature of emotions research can galvanize analytic insight. (shrink)

In his metaphysical summa of 1986, The Plurality of Worlds, David Lewis famously defends a doctrine he calls ‘modal realism’, the idea that to account for the fact that some things are possible and some things are necessary we must postulate an infinity possible worlds, concrete entities like our own universe, but cut off from us in space and time. Possible worlds are required to account for the facts of modality without assuming that modality is primitive – that there are (...) irreducibly modal facts. We argue that on one reading, Lewis’s theory licenses us to assume maverick possible worlds which spread through logical space gobbling up all the rest. Because they exclude alternatives, these worlds result in contradictions, since different spread worlds are incompatible with one another. Plainly Lewis’s theory must be amended to exclude these excluders. But, we maintain, this cannot be done without bringing in modal primitives. And once we admit modal primitives, bang goes the rationale for Lewis’s modal realism. (shrink)

He-Yin Zhen (1886–1920) was a female theorist who played a central role in the birth of Chinese feminism. Editor of a prominent feminist-anarchist journal in the early twentieth century and exponent of a particularly incisive analysis of China and the world. Unlike her contemporaries, He-Yin Zhen was concerned less with China’s fate as a nation and more with the relationship among patriarchy, imperialism, capitalism, and gender subjugation as global and transhistorical problems. Her bold writings were considered radical and dangerous in (...) her lifetime and gradually have been erased from the historical record. This volume, the first translation and study of He-Yin’s work in English or Chinese, is also a critical reconstruction of early twentieth-century Chinese feminist thought in a transnational context. The book repositions He-Yin Zhen as central to the development of feminism in China, juxtaposing her writing with fresh translations of works by two of her better-known male interlocutors. -/- The editors begin with a detailed portrait of He-Yin Zhen’s life and an analysis of her thought in comparative terms. They then present annotated translations of six of her major essays, as well as two foundational tracts by her male contemporaries, Jin Tianhe (1873–1947) and Liang Qichao (1873–1929), to which He-Yin’s work responds and with which it engages. Jin Tianhe, a poet and educator, and Liang Qichao, a philosopher and journalist, understood feminism as a paternalistic cause that “enlightened” male intellectuals like themselves should defend. Zhen counters with an alternative conception of feminism that draws upon anarchism and other radical trends in thought. Ahead of her time within the context of both modernizing China and global feminism, He-Yin Zhen complicates traditional accounts of women and modern history, offering original perspectives on sex, gender, labor, and power that continue to be relevant to feminist theorists in China, Europe, and America. (shrink)

ABSTRACTIn two experiments, we explored whether anecdotal stories influenced how individuals reasoned when evaluating scientific news articles. We additionally considered the role of education level and thinking dispositions on reasoning. Participants evaluated eight scientific news articles that drew questionable interpretations from the evidence. Overall, anecdotal stories decreased the ability to reason scientifically even when controlling for education level and thinking dispositions. Additionally, we found that article length was related to participants' ratings of the news articles. Our study demonstrates that anecdotes (...) can discourage scientific reasoning while also pointing to the potential influence of article length on judgements of quality. (shrink)